Next time I'll just wait for you to answer my question before I post it...

This is a loopback connection: A device simulator is sending data on COM1 and my app is reading it back from COM2 using a null modem cable. I assume you'll agree that the connection itself doesn't get much more stable than that. As I said it's running anywhere between 1 and 3 days before this happens, so watching a break-out box really isn't an option.
Anyway, you confirmed my suspicions that it doesn't have to be a hardware error when you stated that an "unrelated" software error could trigger it. Knowing that gives me a few hints on what to check. Please allow me to suggest that info like that be included in the error description - makes a world of difference to know that when I'm trying to track down one of these things...
Thanks for yet another fast & informative reply!
Ketil
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